BDBM497274 (1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (piperidin-4- ylmethyl)piperidin-4-yl)- 7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol::US11001586, Example 53

SMILES CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(CC2CCNCC2)CC1

InChI Key InChIKey=MFMGCNRBRYJVAT-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 497274   

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 3nMAssay Description:Activity Against Mer Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 750nMAssay Description:Activity Against Tyro3 Tyrosine Kinase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase Mer(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 4nMAssay Description:Inhibition of MERTK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor UFO(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 98nMAssay Description:Inhibition of AXL (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase receptor TYRO3(Human)
The University of North Carolina At Chapel Hill

US Patent
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 33nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
University of North Carolina At Chapel Hill

Curated by ChEMBL
LigandPNGBDBM497274((1S,4R)-4-(2-(((S)-pentan- 2-yl)amino)-5-(1- (pipe...)
Affinity DataIC50: 200nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2022
Entry Details Article
PubMed