BDBM497136 US11001561, Compound 111a::US11702392, Compound 111a

SMILES C[C@@H]1C[C@@H](N)C2(C1)CCN(CC2)c1nc(C)n(-c2cccc(Cl)c2Cl)c(=O)c1C

InChI Key InChIKey=WOCDEPYHPSYTKV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 497136   

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM497136(US11001561, Compound 111a | US11702392, Compound 1...)
Affinity DataIC50: 93nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM497136(US11001561, Compound 111a | US11702392, Compound 1...)
Affinity DataIC50: 93nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent