BDBM497007 US11001561, Compound 4::US11104675, Example 3::US11702392, Compound 4

SMILES Cc1nc(cc(=O)n1-c1cccc(Cl)c1Cl)N1CCC(C)(CN)CC1

InChI Key InChIKey=XVYAPWLPPUVJIR-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 497007   

LigandPNGBDBM497007(US11104675, Example 3 | US11001561, Compound 4 | U...)
Affinity DataIC50: 310nMAssay Description:Phosphatase activity of full length wild-type PTPN11(PTPN11-WT) or PTPN11-E76K mutant enzyme was measured using the fluorogenic 6,8-difluoro-4-methyl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/13/2022
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM497007(US11104675, Example 3 | US11001561, Compound 4 | U...)
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/8/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Merck Patent

US Patent
LigandPNGBDBM497007(US11104675, Example 3 | US11001561, Compound 4 | U...)
Affinity DataIC50: 260nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2023
Entry Details
Go to US Patent