BDBM496109 ALP-POS-02c6a514-57::CVD-0013887::US20240083885, Compound Jun8-50-2

SMILES CC(C)(C)c1ccc(cc1)N(C(C(=O)NCc1ccccc1)c1cccnc1)C(=O)c1ccco1

InChI Key InChIKey=GPFAPGKAYCRHKV-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 496109   

TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM496109(ALP-POS-02c6a514-57 | CVD-0013887 | US20240083885,...)
Affinity DataIC50: 4.36E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM496109(ALP-POS-02c6a514-57 | CVD-0013887 | US20240083885,...)
Affinity DataIC50: 4.36E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM496109(ALP-POS-02c6a514-57 | CVD-0013887 | US20240083885,...)
Affinity DataIC50: 1.32E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Arizona Board Of Regents On Behalf Of The University Of Arizona

US Patent
LigandPNGBDBM496109(ALP-POS-02c6a514-57 | CVD-0013887 | US20240083885,...)
Affinity DataIC50: 13.2nMAssay Description:The main protease (Mpro) enzymatic assays were carried out exact as previously described in pH 6.5 reaction buffer containing 20 mM HEPES pH 6.5, 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent