BDBM495181 1-(3-Chloro-2-fluorobenzyl)-4-(5-morpholino-1H-pyrrolo[2,3-b]pyridin-3-yl)pyridin-2(1H)-one::US10995089, Example 32::US11708364, Example 32

SMILES Fc1c(Cl)cccc1Cn1ccc(cc1=O)-c1c[nH]c2ncc(cc12)N1CCOCC1

InChI Key InChIKey=AMJWCODBEONSSK-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 495181   

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495181(US10995089, Example 32 | 1-(3-Chloro-2-fluorobenzy...)
Affinity DataIC50: 150nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase 1(Human)
Agv Discovery

US Patent
LigandPNGBDBM495181(US10995089, Example 32 | 1-(3-Chloro-2-fluorobenzy...)
Affinity DataIC50: 10nMAssay Description:To assess compounds capacity to inhibit ERK2 enzymatic activity, Z′-Lyte biochemical assay from Life technologies was used according to manufac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2023
Entry Details
Go to US Patent