BDBM495169 3-[(2,4-Dimethylthiazol-5-yl)methyl]-N-(1-methylcyclopropyl)-1-(5-methyl-1,3,4-thiadiazol-2-yl)indole-6-sulfonamide::US10995073, Example 129

SMILES Cc5nnc(n4cc(Cc1sc(C)nc1C)c3ccc(S(=O)(=O)NC2(C)CC2)cc34)s5

InChI Key InChIKey=JARZVIBTIBGCGT-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 495169   

TargetPoly(ADP-ribose) glycohydrolase(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM495169(US10995073, Example 129 | 3-[(2,4-Dimethylthiazol-...)
Affinity DataEC50:  371nMAssay Description:PARG In vitro assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length PARG (Produced internally by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2021
Entry Details
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TargetADP-ribosylhydrolase ARH3(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM495169(US10995073, Example 129 | 3-[(2,4-Dimethylthiazol-...)
Affinity DataIC50: 1.67E+4nMAssay Description:ARH3 In vitro selectivity assays were conducted in a total volume of 15 ul in a standard 384 well format. 5 ul of Human Full Length ARH3 (Enzo Life S...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetPoly [ADP-ribose] polymerase 1(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM495169(US10995073, Example 129 | 3-[(2,4-Dimethylthiazol-...)
Affinity DataIC50: 1.50E+5nMAssay Description:PARP1 In vitro selectivity assays were conducted as a 10 ul reaction volume in a NUNC Maxisorp 384-well assay plate pre-coated in-house with Histones...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent