BDBM495014 US10994015, Example 310

SMILES C[C@H](NC(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@@H](NC(=O)COCCOCCOCCN1CCN(CCOCC#Cc2cccc3CN(C(C(=O)Nc4nccs4)c4cc(F)ccc4O)C(=O)c23)CC1)C(C)(C)C)c1ccc(cc1)-c1scnc1C

InChI Key InChIKey=OTTUDZYAFQYNDQ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 495014   

TargetEpidermal growth factor receptor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM495014(US10994015, Example 310)
Affinity DataIC50: 140nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
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LigandPNGBDBM495014(US10994015, Example 310)
Affinity DataIC50: 6.00E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM495014(US10994015, Example 310)
Affinity DataIC50: 8.40E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Arvinas Operations

US Patent
LigandPNGBDBM495014(US10994015, Example 310)
Affinity DataIC50: 110nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Arvinas Operations

US Patent
LigandPNGBDBM495014(US10994015, Example 310)
Affinity DataIC50: 22nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
Go to US Patent