BDBM494956 US10994015, Example 101

SMILES Clc1ccccc1CNc1ncnc2NC(Cc12)c1ccc(CN2CCN(CCOc3ccc4C(=O)N(C5CCC(=O)NC5=O)C(=O)c4c3)CC2)cc1

InChI Key InChIKey=YXZKPJAWBYYRCB-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 494956   

TargetEpidermal growth factor receptor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM494956(US10994015, Example 101)
Affinity DataIC50: 12nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor(Human)
Arvinas Operations

US Patent
LigandPNGBDBM494956(US10994015, Example 101)
Affinity DataIC50: 69nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [T790M,L858R](Human)
Arvinas Operations

US Patent
LigandPNGBDBM494956(US10994015, Example 101)
Affinity DataIC50: 3.40E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent

TargetEpidermal growth factor receptor [L858R,T790M,C797S](Human)
Arvinas Operations

US Patent
LigandPNGBDBM494956(US10994015, Example 101)
Affinity DataIC50: 3.60E+3nMAssay Description:All compounds and PROTACs were serially diluted in three-fold increments using 100% DMSO, followed by an intermediate 10-fold dilution using Buffer A...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/4/2021
Entry Details
US Patent