BDBM494892 US10988463, Example 21::[(1R,5S,6R)-3-{3-chloro-5-cyano-4-(difluoromethyl)-6-[(2S,3R)-3-hydroxy-2,3-dimethylazetidin-1-yl]pyridin-2-yl}-3-azabicyclo[3.1.0]hex-6-yl]acetic acid

SMILES C[C@@H]1N(C[C@@]1(C)O)c1nc(N2CC3C(CC(O)=O)C3C2)c(Cl)c(C(F)F)c1C#N

InChI Key InChIKey=NQEJWPRACJNXNT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 494892   

TargetKetohexokinase(Human)
Pfizer

US Patent
LigandPNGBDBM494892(US10988463, Example 21 | [(1R,5S,6R)-3-{3-chloro-5...)
Affinity DataIC50: 8.70nMAssay Description:Assay A, a 384-well format on a Corning 3653 assay plate is used, and monitored by UV-vis spectroscopy in continuous mode at rt. Compounds were prepa...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
US Patent