BDBM494675 (2-((4-(N-(6-fluoro-2,3-dihydro-1H- inden-1-yl)-N''- hydroxycarbamimidoyl)-1,2,5- oxadiazol-3-yl)thio)acetamide (chiral, peak 1)::US10988487, Example 71::US10988487, Example 72

SMILES NC(=O)CSc1nonc1\C(NC1CCc2ccc(F)cc12)=N\O

InChI Key InChIKey=INCBUCGDNDFEHC-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 494675   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM494675(US10988487, Example 71 | US10988487, Example 72 | ...)
Affinity DataIC50: 45.1nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM494675(US10988487, Example 71 | US10988487, Example 72 | ...)
Affinity DataIC50: 1.03E+4nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent