BDBM494033 US10988476, Compound I-130

SMILES CC(C)n1c(C)nc2c(F)cc(cc12)-c1nc(Nc2ccc3CN(C[C@H]4CNCCO4)CCc3n2)ncc1F

InChI Key InChIKey=PUXKEKPYASIYGT-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 494033   

TargetCyclin-dependent kinase 4(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 1.02nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 6(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 1.48nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 2(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 14.3nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 1(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 208nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 5(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 85.8nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 7(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 109nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent

TargetCyclin-dependent kinase 9(Human)
Shanghai Pharmaceuticals Holding

US Patent
LigandPNGBDBM494033(US10988476, Compound I-130)
Affinity DataIC50: 20.8nMAssay Description:1. Take 10 mM stock solution of the test compound, in 96-well compound plate, DMSO was used to dilute the compound to an initial concentration of 100...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent