BDBM493620 US10988445, Example 300

SMILES CNS(=O)(=O)c1ccc2C(NCc2c1)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F

InChI Key InChIKey=ATPJQBPMOKBPQM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493620   

TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493620(US10988445, Example 300)
Affinity DataIC50: 50.1nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
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TargetNuclear receptor ROR-gamma(Human)
Astrazeneca

US Patent
LigandPNGBDBM493620(US10988445, Example 300)
Affinity DataIC50: 316nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/1/2021
Entry Details
Go to US Patent