BDBM493017 US10981906, Example 113::ethyl 4-((3-(2-cyanoethoxy)cyclopentyl)amino)-1H- pyrrolo[2,3-b]pyridine-5-carboxylate

SMILES CCOC(=O)c1cnc2[nH]ccc2c1NC1CCC(C1)OCCC#N

InChI Key InChIKey=ONFUEYUMEHPUIF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493017   

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493017(US10981906, Example 113 | ethyl 4-((3-(2-cyanoetho...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493017(US10981906, Example 113 | ethyl 4-((3-(2-cyanoetho...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent