BDBM493013 US10981906, Example 74::ethyl 4-(((1S,3S)-3-(2-cyanoacetoxy)cyclopentyl)amino)- 1H-pyrrolo[2,3-b]pyridine-5-carboxylate

SMILES CCOC(=O)c1cnc2[nH]ccc2c1N[C@H]1CC[C@@H](C1)OC(=O)CC#N

InChI Key InChIKey=QQLRWQWBWOIBAS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 493013   

TargetTyrosine-protein kinase JAK1(Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493013(US10981906, Example 74 | ethyl 4-(((1S,3S)-3-(2-cy...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Aclaris Therapeutics

US Patent
LigandPNGBDBM493013(US10981906, Example 74 | ethyl 4-(((1S,3S)-3-(2-cy...)
Affinity DataIC50: 55nMAssay Description:The activity of JAK3 (a.a. 781-1124, ThermoFisher) was quantified by measuring the phosphorylation of SRCtide (FAM-GEEPLYWSFPAKKK-NH2). Kinase reacti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent