BDBM492986 5-((3,6-difluoro-2-(pyrrolidin-1-ylmethyl)benzyl)amino)-N-(thiazol-4-yl)imidazo[1,2-a]pyridine-8-sulfonamide trifluoroacetic acid salt::US10981905, Example 44::US11639351, Example 44

SMILES Fc1ccc(F)c(CN2CCCC2)c1CNc1ccc(c2nccn12)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=PYXFRBMGNCFAIY-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 492986   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 171nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 8.85E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 2.02E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 171nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 8.85E+3nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492986(US10981905, Example 44 | 5-((3,6-difluoro-2-(pyrro...)
Affinity DataIC50: 2.02E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2023
Entry Details
Go to US Patent