BDBM492964 3-fluoro-5-((2-fluoro-6-((isopropyl(methyl)-amino)methyl)benzyl)amino)-6-methyl-N-(thiazol-4-yl)pyridine-2-sulfonamide::US10981905, Example 35

SMILES CC(C)CNCc1cccc(F)c1CNc1cc(F)c(nc1C)S(=O)(=O)Nc1cscn1

InChI Key InChIKey=YVKXWICRVLIDGE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492964   

TargetSodium channel protein type 8 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492964(US10981905, Example 35 | 3-fluoro-5-((2-fluoro-6-(...)
Affinity DataIC50: 24nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 5 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492964(US10981905, Example 35 | 3-fluoro-5-((2-fluoro-6-(...)
Affinity DataIC50: 3.00E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent

TargetSodium channel protein type 1 subunit alpha(Human)
Xenon Pharmaceuticals

US Patent
LigandPNGBDBM492964(US10981905, Example 35 | 3-fluoro-5-((2-fluoro-6-(...)
Affinity DataIC50: 1.05E+4nMAssay Description:This sodium influx assay employs the use of the cell permeable, sodium sensitive dye ANG2 to quantify sodium ion influx through sodium channels which...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
Go to US Patent