BDBM492696 Preparation of 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(2-fluoro-4-((5-methoxy-2,3-dihydro-[1,4]dioxino[2,3-f]quinoline-10-yl)oxy)phenyl)urea::US10980809, Example 92::US11479559, Example 6

SMILES COc1cc2nccc(Oc3ccc(NC(=O)Nc4ccc(Cl)c(c4)C(F)(F)F)c(F)c3)c2c2OCCOc12

InChI Key InChIKey=ZRWKQWLGULPJKT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 492696   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492696(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 50nMAssay Description:The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds: a total of 11 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492696(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 275nMAssay Description:1. Dilution of the compound: a total of 12 concentrations were obtained using a 4-fold gradient dilution from the highest concentration of 10000 nM (...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/26/2021
Entry Details
US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Beijing Scitech-Mq Pharmaceuticals

US Patent
LigandPNGBDBM492696(Preparation of 1-(4-chloro-3-(trifluoromethyl)phen...)
Affinity DataIC50: 275nMAssay Description:The assay is based on the LANCE TR-FRET technology of Perkin Elmer Inc., and the assay method is as follows:1. Dilution of compounds: a total of 11 c...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2022
Entry Details
US Patent