BDBM491780 4-Chloro-5-(6-((6,6-difluorospiro[3.3]heptan-2-yl)amino)-4-methoxypyridin-3-yl)-1-ethyl-N-(((1r,4r)-4-(methylsulfonyl)cyclohexyl)methyl)-1H-pyrazole-3-carboxamide::US10975057, Example 65

SMILES CCn1nc(C(=O)NC[C@H]2CC[C@@H](CC2)S(C)(=O)=O)c(Cl)c1-c1cnc(NC2CC3(C2)CC(F)(F)C3)cc1OC

InChI Key InChIKey=BEBSTMJTLYPZDK-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 491780   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491780(US10975057, Example 65 | 4-Chloro-5-(6-((6,6-diflu...)
Affinity DataKd:  950nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2021
Entry Details
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