BDBM491745 4-Chloro-5-(4-(difluoromethoxy)-6-(((R*)-1,1,1-trifluoro-3-methylbutan-2-yl)amino)pyridin-3-yl)-1-ethyl-N-(((1s,4S)-1-hydroxy-4-(methylsulfonyl)cyclohexyl)methyl)-1H-pyrazole-3-carboxamide::US10975057, Example 29

SMILES CCn1nc(C(=O)NC[C@@]2(O)CC[C@@H](CC2)S(C)(=O)=O)c(Cl)c1-c1cnc(N[C@H](C(C)C)C(F)(F)F)cc1OC(F)F

InChI Key InChIKey=YZVTUBQSJXYKAF-UHFFFAOYSA-N

Data  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 491745   

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM491745(US10975057, Example 29 | 4-Chloro-5-(4-(difluorome...)
Affinity DataKd:  3.10nMAssay Description:For the RORγt construct used in the ThermoFluor assay, numbering for the nucleotide sequences was based on the reference sequence for human ROR&...More data for this Ligand-Target Pair
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Date in BDB:
10/20/2021
Entry Details
US Patent