BDBM490783 US10968242, Example 13 Peak 2

SMILES Nc1ncnc2n(cnc12)[C@@H]1C[C@@H]2OP(S)(=O)O[C@@H]3[C@@H](CSP(S)(=O)O[C@@H]1[C@H]2O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12

InChI Key InChIKey=HPWPOIRHJIXNFD-UHFFFAOYSA-N

Data  1 KI  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 490783   

LigandPNGBDBM490783(US10968242, Example 13 Peak 2)
Affinity DataKd:  4.57E+3nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490783(US10968242, Example 13 Peak 2)
Affinity DataKd:  5.98E+3nMAssay Description:Surface plasmon resonance (SPR) STING agonist binding studies were carried out using a Biacore T200 instrument (GE Healthcare) at 4° C. in a 150 mM K...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein(Human)
Pfizer

US Patent
LigandPNGBDBM490783(US10968242, Example 13 Peak 2)
Affinity DataKi: >1.00E+3nMAssay Description:A radioligand binding assay was developed to determine compound interactions were competitive with a tritium-labeled version of the native STING liga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent