BDBM490518 N-(2,6-dichlorophenyl)-5-fluoro-4-(3-oxo-5,6-dihydro-3H-[1,2,4]triazolo[3,4-c][1,4]oxazin-2(8H)-yl)-2-{[(2S)-1,1,1-trifluoropropan-2-yl]oxy}benzamide::US10968216, Example 186

SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1c(Cl)cccc1Cl)-n1nc2COCCn2c1=O)C(F)(F)F

InChI Key InChIKey=GSLQGILDUOEVAA-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490518   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
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US Patent
LigandPNGBDBM490518(US10968216, Example 186 | N-(2,6-dichlorophenyl)-5...)
Affinity DataIC50: 5.30nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
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Date in BDB:
10/9/2021
Entry Details
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