BDBM490472 N-[4-amino-2-(trifluoromethyl)phenyl]-2-[(1S)-1-cyclohexylethoxy]-5-fluoro-4-(3-oxo-5,6,7,8 tetrahydro[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)benzamide::US10968216, Example 140

SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ccc(N)cc1C(F)(F)F)-n1nc2CCCCn2c1=O)C1CCCCC1

InChI Key InChIKey=SXMXQZKGGKLCIS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 490472   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490472(US10968216, Example 140 | N-[4-amino-2-(trifluorom...)
Affinity DataIC50: 5nMAssay Description:Assay 1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
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TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Human)
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490472(US10968216, Example 140 | N-[4-amino-2-(trifluorom...)
Affinity DataIC50: 128nMAssay Description:Assay 2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent