BDBM490116 US10968199, Example 27

SMILES C[C@H](CO)n1cnnc1-c1cccc(NC(=O)c2cc(C3CC3NS(=O)(=O)CCC(F)(F)F)c(C)cc2F)n1

InChI Key InChIKey=UHXMWIORJCYBIT-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 490116   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM490116(US10968199, Example 27)
Affinity DataIC50: 5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF KinEASE Assay System was obtained fro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent