BDBM490075 US10968199, Example 1::US10968199, Example 30

SMILES CCOC(=O)C1CC1c1cc(C(=O)Nc2cccc(n2)-c2nncn2C(C)C)c(F)cc1C

InChI Key InChIKey=WJSQGROIWKHOKI-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 490075   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM490075(US10968199, Example 1 | US10968199, Example 30)
Affinity DataIC50: 5.5nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF KinEASE Assay System was obtained fro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Enanta Pharmaceuticals

US Patent
LigandPNGBDBM490075(US10968199, Example 1 | US10968199, Example 30)
Affinity DataIC50: 10nMAssay Description:ASK1 was purchased from Thermofisher (Catalogue #PV4011), ATP was purchased from Sigma (Catalogue #A7699), HTRF KinEASE Assay System was obtained fro...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2021
Entry Details
Go to US Patent