BDBM489619 (R)-4-(4-amino-8- fluoro-6,7-dimethoxy- quinazolin-2-yl)-1- (3-(ethylamino)-3- (4-fluorophenyl)- propanoyl)-1,2,5,6- tetrahydropyridine- 3-carboxylic acid::US10961252, Cmp No. 8::US11248000, Cmp No. 8

SMILES CCN[C@H](CC(=O)N1CCC(=C(C1)C(O)=O)c1nc(N)c2cc(OC)c(OC)c(F)c2n1)c1ccc(F)cc1

InChI Key InChIKey=HMXCWZWTKLHSGU-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489619   

TargetComplement factor B(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489619(US10961252, Cmp No. 8 | (R)-4-(4-amino-8- fluoro-6...)
Affinity DataIC50: 1.00E+4nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetCobra venom factor/Complement factor B/Complement factor D(Monocled cobra)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489619(US10961252, Cmp No. 8 | (R)-4-(4-amino-8- fluoro-6...)
Affinity DataIC50: 1.00E+4nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent