BDBM489612 1-(4-(4-amino-8- fluoro-6,7-dimethoxy- quinazolin-2-yl)- piperazin-1-yl)-2- ((2S,3aS,6aS)- octahydrocyclopenta- [b]pyrrol-2-ylethan- 1-one hydrochloride::US10961252, Cmp No. 2::US11248000, Cmp No. 2

SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)C[C@@H]1C[C@@H]2CCC[C@@H]2N1

InChI Key InChIKey=SIQAOUJCAHLJBY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489612   

TargetComplement factor B(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489612(US10961252, Cmp No. 2 | 1-(4-(4-amino-8- fluoro-6,...)
Affinity DataIC50: 1.00E+3nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetCobra venom factor/Complement factor B/Complement factor D(Monocled cobra)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489612(US10961252, Cmp No. 2 | 1-(4-(4-amino-8- fluoro-6,...)
Affinity DataIC50: 1.00E+3nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
Go to US Patent