BDBM489611 1-(4-(4-amino-8- fluoro-6,7-dimethoxy- quinazolin-2-yl)- piperazin-1-yl)-2- (thiazolidin-2-yl)- ethan-1-one hydro- chloride::US10961252, Cmp No. 1::US11248000, Cmp No. 1

SMILES COc1cc2c(N)nc(nc2c(F)c1OC)N1CCN(CC1)C(=O)CC1NCCS1

InChI Key InChIKey=GKALIANZJAECLA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489611   

TargetCobra venom factor/Complement factor B/Complement factor D(Monocled cobra)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489611(US10961252, Cmp No. 1 | 1-(4-(4-amino-8- fluoro-6,...)
Affinity DataIC50: 1.00E+4nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/13/2022
Entry Details
US Patent

TargetComplement factor B(Human)
Achillion Pharmaceuticals

US Patent
LigandPNGBDBM489611(US10961252, Cmp No. 1 | 1-(4-(4-amino-8- fluoro-6,...)
Affinity DataIC50: 1.00E+4nMAssay Description:CVF-Bb complex is prepared from purified cobra venom factor (1 μM); human Complement factor B and human Complement factor D are available from a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
US Patent