BDBM489405 US10961247, Ex. No. 20

SMILES COc1cccc(Cn2cc(Nc3nc(N[C@@H]4CCCN(C4)C(=O)C=C)c4cc[nH]c4n3)cn2)c1

InChI Key InChIKey=JMHRTCGJMCDNRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 489405   

TargetTyrosine-protein kinase JAK3(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489405(US10961247, Ex. No. 20)
Affinity DataIC50: 0.700nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Daewoong Pharmaceutical

US Patent
LigandPNGBDBM489405(US10961247, Ex. No. 20)
Affinity DataIC50: 9.5nMAssay Description:JAK3 and BTK kinase inhibitory activities were measured for the compounds prepared in the above Examples through in vitro analysis on the ADP Glow (G...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent