BDBM489273 2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-[4-methyl-2-({6-[(2R)-2-methyl-6-oxopiperazin-1-yl]pyridin-2-yl}amino)-1,3-thiazol-5-yl]-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 46
SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2[C@H](C)CNCC2=O)nc1C
InChI Key InChIKey=TYTHLOGWHWLWET-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 489273
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 0.800nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform [144-1102](Human)
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 1nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 24nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Astrazeneca
US Patent
Astrazeneca
US Patent
Affinity DataIC50: 123nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair