BDBM489256 6-(4-Methyl-2-{[6-(2-oxo-1,3-oxazinan-3-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-3-oxo-N-(propan-2-yl)-2-[(2S)-1,1,1-trifluoropropan-2-yl]-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 29

SMILES CC(C)NS(=O)(=O)c1cc(cc2CN([C@@H](C)C(F)(F)F)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCCOC2=O)nc1C

InChI Key InChIKey=KFNBJCXUFADQNW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489256   

LigandPNGBDBM489256(US10961236, Example 29 | 6-(4-Methyl-2-{[6-(2-oxo-...)
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
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LigandPNGBDBM489256(US10961236, Example 29 | 6-(4-Methyl-2-{[6-(2-oxo-...)
Affinity DataIC50: 2.20nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489256(US10961236, Example 29 | 6-(4-Methyl-2-{[6-(2-oxo-...)
Affinity DataIC50: 47nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489256(US10961236, Example 29 | 6-(4-Methyl-2-{[6-(2-oxo-...)
Affinity DataIC50: 62nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent