BDBM489253 N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(ethylsulfamoyl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-4-methyl-1,3-thiazol-2-yl)amino]pyridin-2-yl}-2-methoxy-N-methylacetamide::US10961236, Example 26

SMILES CCNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N(C)C(=O)COC)nc1C

InChI Key InChIKey=TZUURZCAUFJVTJ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489253   

LigandPNGBDBM489253(US10961236, Example 26 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
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LigandPNGBDBM489253(US10961236, Example 26 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 1.10nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489253(US10961236, Example 26 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 110nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489253(US10961236, Example 26 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 562nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent