BDBM489245 N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsulfamoyl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl}-4-methyl-1,3-thiazol-2-yl)amino]pyridin-2-yl}-N-ethyl-2-methoxyacetamide::US10961236, Example 18

SMILES CCN(C(=O)COC)c1cccc(Nc2nc(C)c(s2)-c2cc3CN([C@@H](C)C4CC4)C(=O)c3c(c2)S(=O)(=O)NC)n1

InChI Key InChIKey=MZRYOHCLXSQOIU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489245   

LigandPNGBDBM489245(US10961236, Example 18 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 0.300nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
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LigandPNGBDBM489245(US10961236, Example 18 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 0.800nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489245(US10961236, Example 18 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 25nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

LigandPNGBDBM489245(US10961236, Example 18 | N-{6-[(5-{2-[(1S)-1-Cyclo...)
Affinity DataIC50: 231nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent