BDBM488779 (R)-N-(3-(5-fluoro-2- (2-fluoro-3- (methylsulfonyl)phenyl amino)pyrimidin-4-yl)- 1H-indol-7-yl)-3- methoxy-2-(4- methylpiperazin-1- yl)propanamide::US10961228, Example 35

SMILES COC[C@@H](N1CCN(C)CC1)C(=O)Nc1cccc2c(c[nH]c12)-c1nc(Nc2cccc(c2F)S(C)(=O)=O)ncc1F

InChI Key InChIKey=JNUZADQZHYFJGW-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 488779   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 1.22E+3nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/4/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant JAK1 (866 to 1154 residues) expressed in insect cells using FITC-C6-KKHTDDGYMPMSPGVA-NH peptide...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant JAK2 (831 to 1132 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST-tagged human recombinant JAK3 (781 to 1124 residues) expressed in insect cells using 5FAM-GEEPLYWSFPAKKK-NH2 peptide as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK1(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 0.540nMAssay Description:Inhibition of GST-tagged human recombinant JAK1 (866 to 1154 residues) expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 686nMAssay Description:Inhibition of GST-tagged human recombinant JAK2 (809 to 1153 residues) expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetTyrosine-protein kinase JAK3(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged human recombinant JAK3 (781 to 1124 residues) expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM488779(US10961228, Example 35 | (R)-N-(3-(5-fluoro-2- (2-...)
Affinity DataIC50: 657nMAssay Description:Inhibition of GST-tagged human recombinant TYK2 (833 to 1187 residues) expressed in insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed