BDBM488409 2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]triazin-5-yl]-3-chloro-N-methyl-1H-indole- 6-carboxamide::US10954241, Example 49::US11548896, Example 49

SMILES CNC(=O)c1ccc2c(Cl)c([nH]c2c1)-c1nc(C(C)C)n2ncnc(N)c12

InChI Key InChIKey=VYARLCVNNHTNAM-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 488409   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 5.41nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 4.20E+3nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 16.2nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 5.41nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent

TargetVascular endothelial growth factor receptor 2(Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 4.20E+3nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent

TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Human)
Cancer Research Technology

US Patent
LigandPNGBDBM488409(2-[4-Amino-7-(propan-2-yl)imidazo[4,3- f][1,2,4]tr...)
Affinity DataIC50: 16.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2023
Entry Details
Go to US Patent