BDBM488343 US10954240, Example 47

SMILES C[C@H]1CN(C[C@@H](C)O1)c1cc(ccn1)-n1ncc2ccc(cc12)-c1cnn(C)c1

InChI Key InChIKey=JLBMPAIKDCGEES-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 488343   

LigandPNGBDBM488343(US10954240, Example 47)
Affinity DataIC50: 32nMAssay Description:LRRK2 Km ATP LanthaScreen Assaya) 400 nl of a 1:2.15 serial dilution of test compound (98 μM top assay concentration) is spotted via Labcyte Ech...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
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LigandPNGBDBM488343(US10954240, Example 47)
Affinity DataIC50: 100nMAssay Description:Inhibition of GST20-tagged human LRRK2 G2019S mutant using LRRKtide peptide preincubated for 15 mins followed by substrate addition and measured afte...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed
LigandPNGBDBM488343(US10954240, Example 47)
Affinity DataIC50: 120nMAssay Description:Inhibition of GST20-tagged LRRK2 in human SH-SY5Y cells assessed as reduction in pSer935 phosphorylation incubated for 90 mins by MSD assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2024
Entry Details
PubMed