BDBM488109 N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4-yl)pyrimidin-2-yl)-2- (2-methoxyethyl)- 1,2,3,4- tetrahydroisoquinolin- 6-amine::US10954216, Example 126

SMILES CCn1cc(c(n1)-c1cccnc1)-c1ccnc(Nc2ccc3CN(CCOC)CCc3c2)n1

InChI Key InChIKey=VGZWCYQORLDLNN-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 488109   

TargetActivin receptor type-1(Human)
Riken

US Patent
LigandPNGBDBM488109(N-(4-(1-Ethyl-3- (pyridin-3-yl)-1H- pyrazol-4-yl)p...)
Affinity DataIC50: 15nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
US Patent