BDBM487227 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluorophenyl)-2-methylpyrazolo[1,5-a]pyrimidin-7(4H)-one::US10953012, Example 81

SMILES Cc1nn2c([nH]c(cc2=O)-c2ccc3OCCOc3c2)c1-c1ccc(F)cc1

InChI Key InChIKey=NJZWUOQHXNFEFV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 487227   

LigandPNGBDBM487227(5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 2: Purified PASK (UniProt #Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
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LigandPNGBDBM487227(5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Table 3: In the presence of kinase and ATP, the Ulight-peptide is phosphorylated and captured by an anti-phospho-substrate antibody, which brings the...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
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TargetCasein kinase II subunit alpha'(Human)
Bioenergenix

US Patent
LigandPNGBDBM487227(5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(4-fluor...)
Affinity DataIC50: 1.00E+4nMAssay Description:Purified CK2a2 (NP_001887; human full-length protein, GST tagged) from insect cells (final concentration 1.2 nM) is added to freshly prepared Base Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2021
Entry Details
Go to US Patent