BDBM484868 US10934302, Example 119

SMILES c1ccc2c(c1)[C@H](C3(O2)CCN(CC3)c4cnc5c(n4)[nH]nc5N6CCCc7c6cccn7)N

InChI Key InChIKey=RGCGBFIARQENML-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 484868   

TargetSH2B adapter protein 2(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM484868(US10934302, Example 119)
Affinity DataIC50: 50nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484868(US10934302, Example 119)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484868(US10934302, Example 119)
Affinity DataIC50: 170nMAssay Description:Inhibition of full-length SHP2 E76K mutant (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)