BDBM484776 US10934302, Example 25

SMILES N[C@@H]1c2ccccc2CC11CCN(CC1)c1cnc2c(n[nH]c2n1)N1CCCc2ncccc12

InChI Key InChIKey=RCMXTQBSXNWBDF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484776   

TargetSH2B adapter protein 2(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM484776(US10934302, Example 25)
Affinity DataIC50: 50nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent

TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Relay Therapeutics

Curated by ChEMBL
LigandPNGBDBM484776(US10934302, Example 25)
Affinity DataIC50: 1nMAssay Description:Inhibition of wild-type full-length SHP2 (unknown origin) expressed in Escherichia coli BL21(DE3) using DiFMUP as substrate preincubated for 30 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2024
Entry Details
PubMed