BDBM484771 US10934302, Example 20::US12209074, Example 1

SMILES Cc1nc(N2CCC3(Cc4ccccc4[C@H]3N)CC2)c(CO)nc1-c1cccc(Cl)c1Cl

InChI Key InChIKey=DKKQZPVCISDBHD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484771   

TargetSH2B adapter protein 2(Human)
Relay Therapeutics

US Patent
LigandPNGBDBM484771(US10934302, Example 20 | US12209074, Example 1)
Affinity DataIC50: 50nMAssay Description:SHP2 is allosterically activated through binding of bis-tyrosyl-phorphorylated peptides to its Src Homology 2 (SH2) domains. The latter activation st...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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TargetTyrosine-protein phosphatase non-receptor type 11(Human)
Beijing Shenogen Pharma Group

US Patent
LigandPNGBDBM484771(US10934302, Example 20 | US12209074, Example 1)
Affinity DataIC50: 9nMAssay Description:The basic principle is: SHP2 as phosphatase can catalyze the dephosphorization of DiFMUP to form DiFMU and free phosphate groups. The product DiFMU e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/3/2025
Entry Details
Go to US Patent