BDBM484458 US10934285, Example 44

SMILES CC1(N)CCN(CC1)c1cnc(Sc2cccc(NC(=O)c3c(O)nc4CCCCn4c3=O)c2Cl)cn1

InChI Key InChIKey=BXMQYJKUPLIVAX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 484458   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484458(US10934285, Example 44)
Affinity DataIC50: 14nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
US Patent