BDBM484446 US10934285, Example 32

SMILES CC1(CN)CCN(CC1)c1nnc(Sc2cccc(NC(=O)c3c(O)nc4sccn4c3=O)c2Cl)c(N)n1

InChI Key InChIKey=LHOVPTWWNUDVJH-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 484446   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484446(US10934285, Example 32)
Affinity DataIC50: 8nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
Go to US Patent