BDBM484441 N-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-2-hydroxy-4-oxo-6,7,8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidine-3-carboxamide::US10934285, Example 27::US12053470, Compound 45

SMILES C[C@@H]1OCC2(CCN(CC2)c2cnc(Sc3cccc(NC(=O)c4c(O)nc5CCCCn5c4=O)c3Cl)c(N)n2)[C@@H]1N

InChI Key InChIKey=NGJFCIYVFFUILZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484441   

TargetSH2B adapter protein 2(Human)
Novartis

US Patent
LigandPNGBDBM484441(N-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8...)
Affinity DataIC50: 23nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2021
Entry Details
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LigandPNGBDBM484441(N-(3-((3-Amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8...)
Affinity DataIC50: 23nMAssay Description:More specifically, the phosphatase reactions were performed at room temperature in 384-well black polystyrene plate, flat bottom, low flange, non-bin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2024
Entry Details
Go to US Patent