BDBM484194 UAWJ9-36-1

SMILES O=C[C@H](C[C@@H]1CCNC1=O)NC(=O)[C@@H]1[C@H]2CCC[C@H]2CN1C(=O)OCc1ccccc1

InChI Key InChIKey=XXWDDQJFYNJUCB-UHFFFAOYSA-N

Data  14 IC50  7 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 21 hits for monomerid = 484194   

TargetReplicase polyprotein 1ab(HCoV-229E)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  170nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 51nMAssay Description:Inhibition of SARS-CoV-2 Main protease expressed in Escherichia coli preincubated for 30 mins followed by substrate addition and measured for 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMed
TargetSerine protease 1(Human)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 2.00E+4nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetCaspase-3(Human)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 2.00E+4nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetCathepsin K(Human)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 6.5nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetProcathepsin L(Human)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 1.37E+3nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetCalpain-1 catalytic subunit(Human)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 1.66E+4nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 51nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  440nMAssay Description:CPE assay was carried out in Huh-7 cells in the presence or absence of P-glycoprotein inhibitor CP-100356.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  480nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  1.31E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 51nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  46nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  5.24E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Cac...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University of Palermo

Curated by ChEMBL
LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataEC50:  2.56E+3nMAssay Description:The analyses of antiviral activities of UAWJ9-36-1 (A, C) and UAWJ9-36-3 (B, D) against SARS-CoV-2 in immunofluorescence assay was carried out in Ver...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-HKU1)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 120nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 360nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 100nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetOrf1a protein(MERS-CoV)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 110nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
The University of Arizona

LigandPNGBDBM484194(UAWJ9-36-1)
Affinity DataIC50: 130nMAssay Description:Enzymatic inhibition of GC-376, UAWJ9-36-1, and UAWJ9-36-3 against Mpro's from all seven human coronaviruses. Data fittings of the proteolytic progre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2021
Entry Details Article
PubMed