BDBM484153 (R)-4-((4-ethyl-2-methyl-3- oxo-1-oxa-4,9- diazaspiro[5.5]undecan-9- yl)methyl)benzonitrile::US10927128, Example 74::US11649248, Example 74

SMILES CCN1CC2(CCN(Cc3ccc(cc3)C#N)CC2)O[C@H](C)C1=O

InChI Key InChIKey=YESJSCWXDYQFHB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 484153   

TargetAP-4 complex subunit sigma-1(Human)
Esteve Pharmaceuticals.

US Patent
LigandPNGBDBM484153((R)-4-((4-ethyl-2-methyl-3- oxo-1-oxa-4,9- diazasp...)
Affinity DataKi: <100nMAssay Description:To investigate binding properties of test compounds to human Sigma-1 receptor, transfected HEK-293 membranes and [3H](+)-pentazocine (Perkin Elmer, N...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
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TargetSigma non-opioid intracellular receptor 1(Human)
Esteve Pharmaceuticals

US Patent
LigandPNGBDBM484153((R)-4-((4-ethyl-2-methyl-3- oxo-1-oxa-4,9- diazasp...)
Affinity DataKi: <100nMAssay Description:To investigate binding properties of test compounds to human σ1 receptor, transfected HEK-293 membranes and [3H](+) -pentazocine (Perkin Elmer, ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
Go to US Patent