BDBM483979 7,7-difluoro-N-(2-fluoro-4-methyl-5- (7-methyl-2-(methylamino)pyrido[2,3- d]pyrimidin-6-yl)phenyl)-2- azaspiro[4.4]nonane-2-carboxamide::US10927111, Example 15::US11667634, Example 15

SMILES CNc1ncc2cc(c(C)nc2n1)-c1cc(NC(=O)N2CCC3(CCC(F)(F)C3)C2)c(F)cc1C

InChI Key InChIKey=UFGWEYLGKMQRBP-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483979   

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM483979(7,7-difluoro-N-(2-fluoro-4-methyl-5- (7-methyl-2-(...)
Affinity DataIC50: 10nMAssay Description:Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/9/2023
Entry Details
Go to US Patent

TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Kinnate Biopharma

US Patent
LigandPNGBDBM483979(7,7-difluoro-N-(2-fluoro-4-methyl-5- (7-methyl-2-(...)
Affinity DataIC50: 0.100nMAssay Description:Protein kinase assay: Assay platform was used to measure kinase/inhibitor interactions as described previously (Anastassiadis et al., 2011). In brief...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent