BDBM483713 1-(2-(4-(pyrrolidin- 1-yl)-2- (trifluoromethyl)- benzyl)-2,8- diazaspiro[4.5]- decane-8- carbonyl)-1H- pyrazole-3- carboxamide::US10927105, Ex 195::US11655217, Example 195

SMILES NC(=O)c1ccn(n1)C(=O)N1CCC2(CCN(Cc3ccc(cc3C(F)(F)F)N3CCCC3)C2)CC1

InChI Key InChIKey=JRUSLERHOKHAKP-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 483713   

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483713(US10927105, Ex 195 | 1-(2-(4-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetFatty acid 2-hydroxylase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483713(US10927105, Ex 195 | 1-(2-(4-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483713(US10927105, Ex 195 | 1-(2-(4-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483713(US10927105, Ex 195 | 1-(2-(4-(pyrrolidin- 1-yl)-2-...)
Affinity DataIC50: 100nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent