BDBM483658 1-(4-((3-chloro-5- fluorobenzyl)oxy)- piperidine-1- carbonyl)-1H- pyrazole-3- carboxylic acid::US10927105, Ex 42::US11655217, Example 42

SMILES OC(=O)c1ccn(n1)C(=O)N1CCC(CC1)OCc1cc(F)cc(Cl)c1

InChI Key InChIKey=NLFSKIGXUASJNM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 483658   

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483658(1-(4-((3-chloro-5- fluorobenzyl)oxy)- piperidine-1...)
Affinity DataIC50: 550nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
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TargetFatty acid 2-hydroxylase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483658(1-(4-((3-chloro-5- fluorobenzyl)oxy)- piperidine-1...)
Affinity DataIC50: 550nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
Go to US Patent

TargetMonoglyceride lipase(Human)
Lundbeck La Jolla Research Center

US Patent
LigandPNGBDBM483658(1-(4-((3-chloro-5- fluorobenzyl)oxy)- piperidine-1...)
Affinity DataIC50: 550nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent

TargetFatty-acid amide hydrolase 1(Human)
H. Lundbeck

US Patent
LigandPNGBDBM483658(1-(4-((3-chloro-5- fluorobenzyl)oxy)- piperidine-1...)
Affinity DataIC50: 550nMAssay Description:Proteomes (mouse brain membrane fraction for mouse assays; human prefrontal cortex membrane fractions for human assays) (50 mL, 1.0 mg/mL total prote...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
Go to US Patent