BDBM483594 N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-yl]-N''-hydroxy-4-({2-[N-(2- hydroxyethyl)-S- methylsulfonimidoyl]ethyl}amino)-1,2,5- oxadiazole-3-carboximidamide (isomer 1)::US10927086, Example 57::US10927086, Example 58

SMILES CS(=O)(CCNc1nonc1\C(N[C@H]1Cc2ccc(F)cc12)=N/O)=NCCO

InChI Key InChIKey=YDOQIORTBGMJHM-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483594   

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483594(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50: 70.6nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent

TargetIndoleamine 2,3-dioxygenase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM483594(N-[(7S)-4-fluorobicyclo[4.2.0]octa-1,3,5- trien-7-...)
Affinity DataIC50: 125nMAssay Description:HIS-tagged IDO1 protein was recombinantly expressed in Escherichia coli using ZYP5052 autoinduction media supplemented with 500 μM delta aminole...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent