BDBM483490 US10925881, Name (S)-JQ33

SMILES Cc1sc-2c(c1C)C(=N[C@@H](CC(=O)NCCN1CCOCC1)c1nnc(C)n-21)c1ccc(Cl)cc1

InChI Key InChIKey=KULOTNHGHJGDQB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 483490   

TargetBromodomain-containing protein 4 [349-460](Human)
Tensha Therapeutics

US Patent
LigandPNGBDBM483490(US10925881, Name (S)-JQ33)
Affinity DataIC50: 29.5nMAssay Description:The binding activity of lead compounds with the BRD4 site 2 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent

TargetBromodomain-containing protein 4 [44-167](Human)
Tensha Therapeutics

US Patent
LigandPNGBDBM483490(US10925881, Name (S)-JQ33)
Affinity DataIC50: 85nMAssay Description:The binding activity of lead compounds with the BRD4 site 1 was determined by Alpha-assay with a 12-point dose response curveMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/6/2021
Entry Details
US Patent